РЕСВЕРАТРОЛ: МЕТАБОЛИЗМ, БИОЛОГИЧЕСКИЕ МЕХАНИЗМЫ И ВОЗМОЖНЫЕ ПОБОЧНЫЕ ЭФФЕКТЫ
Аннотация
Ресвератрол, природное соединение из класса стильбенов, содержащееся в винограде, ягодах и других растениях, привлекает значительный научный интерес благодаря широкому спектру заявленных полезных свойств, включая антиоксидантную, противовоспалительную, антивозрастную и кардиопротекторную активность. Данный обзор обобщает современные знания о ресвератроле, исследуя его сложную фармакокинетику — характеризующуюся высоким всасыванием, но низкой биодоступностью при пероральном приёме из-за интенсивного пресистемного метаболизма — и его многообразные механизмы действия. Подробно описана активация ключевых сигнальных путей, таких как SIRT1, AMPK, Nrf2 и PGC-1α, которые опосредуют его влияние на митохондриальный биогенез, антиоксидантную защиту и метаболический гомеостаз. Особое внимание уделено ключевой роли микробиоты кишечника в метаболизме ресвератрола до активных производных, таких как дигидроресвератрол и лунуларин, которые вносят существенный вклад в его биологические эффекты и модулируют состояние желудочно-кишечного тракта. Парадоксально, но в обзоре также рассматриваются потенциальные неблагоприятные эффекты соединения, изучается, как его окисление до реакционноспособной хинонной формы может приводить к про-оксидантным эффектам, генотоксичности, нарушению клеточной сигнализации и эндокринным нарушениям. Этот всесторонний анализ подчеркивает двойственную природу ресвератрола, выделяя как его терапевтический потенциал, так и зависящие от дозы риски, которые необходимо учитывать для его будущего применения в питании и медицине.
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Литература
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Опубликована
2026-01-14
Как цитировать
ЦЕЙЛИКМАН, Вадим Эдуардович et al.
РЕСВЕРАТРОЛ: МЕТАБОЛИЗМ, БИОЛОГИЧЕСКИЕ МЕХАНИЗМЫ И ВОЗМОЖНЫЕ ПОБОЧНЫЕ ЭФФЕКТЫ.
Вестник Челябинского государственного университета. Образование и здравоохранение, [S.l.], n. 3(31), p. 71-90, jan. 2026.
ISSN 2409-4102. Доступно на: <https://journals.csu.ru/index.php/vcsu_eh/article/view/3133>. Дата доступа: 14 apr. 2026
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ресвератрол, метаболиты, микробиота, метаболические пути, молекулярные механизмы действия, о-хинон
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